| Automated stereotactic standardization of brain SPECT receptor data using single-photon transmission images. | |
| | |
MedLine Citation:
|
PMID: 11216537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intra- or intersubject registration of anatomically poorly defined SPECT data, such as in neuroreceptor imaging, is important for longitudinal or group analysis. However, accurate registration is difficult with only emission CT (ECT) data. We investigated fully automated registration using transmission CT (TCT) data as an intermediary image set. METHODS: The accuracy of TCT registration was compared to that of ECT registration for four types of data: gray-matter distribution (with [99mTc]ethylcysteinate dimer (ECD)), neocortical distribution (with [123I]R91150, a highly specific 5-HT2a receptor ligand), and striatal distribution of the D2-receptor ligand (with [123I]iodobenzamide (IBZM)) and the dopamine transporter ligand (with [123I]2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CIT)). In total, 10 datasets of the various study types were used, all collected on a Toshiba GCA9300 gamma camera with super-high-resolution fanbeam collimators and 3 x 370 MBq of 153Gd transmission sources (4-min sequential TCT scanning for receptor studies and 20-min simultaneous scanning for [99mTc]ECD studies). Per dataset, 15 random misalignments of 9 rigid-body parameters (translation, rotation, and anisotropic scaling) were conducted. All coregistrations were done twice, both to the subject's original scan and to a study-specific template. This was done manually by two independent experienced observers and with three automated voxel similarity algorithms: mutual information (M.I.), count difference (C.D.), and uniformity index (U.I.). As an outcome measure, the impact of misregistration on semiquantification for the various study types was established. RESULTS: TCT matching allowed registration within 3.3 mm, 2.4 degrees, and 1.2% scaling (mean squared values for all directions) with an overall accuracy decrease in the following order: C.D. > M.I. > manual > U.I. For [99mTc]ECD and [123I]IBZM, TCT registration was as accurate as ECT registration, while it was far superior for the other receptor data types, especially for abnormal studies. The automated TCT registration accuracy corresponded to average quantification errors of 2.9% ([99mTc]ECD), 4.2% ([123I]BZM), 5.7% ([123I]R91150), and 6.1% ([123I]beta-CIT). CONCLUSION: Fully automated registration through intermediary TCT images is clinically feasible, fast, and accurate. In addition to nonuniform attenuation correction, TCT scanning therefore allows coregistration for group comparisons of SPECT receptor data on a standardized or pixel-by-pixel basis. |
| | |
Authors:
|
K Van Laere; M Koole; Y D'Asseler; J Versijpt; K Audenaert; F Dumont; R Dierckx |
Related Documents
:
|
22228127 - Ct diagnosis of the nature of bowel obstruction: morphological evaluation of the transi... 18334857 - Comparison of atlas- and magnetic-resonance-imaging-based stereotactic targeting of the... 21761267 - Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector spect... 21596707 - Manganese toxicity in a child with iron deficiency and polycythemia. 10464797 - Pseudomembranous colitis: spectrum of imaging findings with clinical and pathologic cor... 19837567 - The effect of clozapine on regional cerebral blood flow and brain metabolite ratios in ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 42 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 2001 Feb |
Date Detail:
|
Created Date: 2001-02-16 Completed Date: 2001-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 361-75 Citation Subset: IM |
Affiliation:
|
Nuclear Medicine Division, Ghent University Hospital, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Benzamides / diagnostic use Brain / radionuclide imaging* Brain Chemistry Cocaine / analogs & derivatives, diagnostic use Cysteine / analogs & derivatives*, diagnostic use Female Humans Image Processing, Computer-Assisted Iodine Radioisotopes / diagnostic use Male Middle Aged Organotechnetium Compounds / diagnostic use Piperidines / diagnostic use Radiopharmaceuticals / diagnostic use Receptors, Dopamine / analysis* Receptors, Serotonin / analysis* Stereotaxic Techniques Tomography, Emission-Computed, Single-Photon* / standards |
| Chemical | |
Reg. No./Substance:
|
0/Benzamides; 0/Iodine Radioisotopes; 0/Organotechnetium Compounds; 0/Piperidines; 0/R 91150; 0/Radiopharmaceuticals; 0/Receptors, Dopamine; 0/Receptors, Serotonin; 0/technetium Tc 99m bicisate; 133647-95-7/RTI 55; 50-36-2/Cocaine; 52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Performance of a dual, solid-state intraoperative probe system with 18F, 99mTc, and (111)In.
Next Document: Biodistribution and radiation dosimetry of the dopamine transporter ligand.