Document Detail


Automated radiofrequency-based US measurement of common carotid intima-media thickness in RA patients treated with synthetic vs synthetic and biologic DMARDs.
MedLine Citation:
PMID:  23065319     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To compare the carotid intima-media thickness (IMT) assessed with automated radiofrequency-based US in RA patients treated with synthetic vs synthetic and biologic DMARDs and controls.Methods. Ninety-four RA patients and 94 sex- and age-matched controls were prospectively recruited at seven centres. Cardiovascular (CV) risk factors and co-morbidities, RA characteristics and therapy were recorded. Common carotid artery (CCA)-IMT was assessed in RA patients and controls with automated radiofrequency-based US by the same investigator at each centre.Results. Forty-five (47.9%) RA patients had been treated with synthetic DMARDs and 49 (52.1%) with synthetic and biologic DMARDs. There were no significant differences between the RA patients and controls in demographics, CV co-morbidities and CV disease. There were significantly more smokers among RA patients treated with synthetic and biologic DMARDs (P = 0.036). Disease duration and duration of CS and synthetic DMARD therapy was significantly longer in RA patients treated with synthetic and biologic DMARDs (P < 0.0005). The mean CCA-IMT was significantly greater in RA patients treated only with synthetic DMARDs than in controls [591.4 (98.6) vs 562.1 (85.8); P = 0.035] and in RA patients treated with synthetic and biologic DMARDs [591.4 (98.6) vs 558.8 (95.3); P = 0.040). There was no significant difference between the mean CCA-IMT in RA patients treated with synthetic and biologic DMARDs and controls (P = 0.997).Conclusion. Our results suggest that radiofrequency-based measurement of CCA-IMT can discriminate between RA patients treated with synthetic DMARDs vs RA patients treated with synthetic and biologic DMARDs.
Authors:
Esperanza Naredo; Ingrid Möller; Alfonso Corrales; David A Bong; Tatiana Cobo-Ibáñez; Hector Corominas; Ma Luz Garcia-Vivar; Pilar Macarrón; Teresa Navio; Patricia Richi; Annamaria Iagnocco; Jesús Garrido; David Martínez-Hernández
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-12
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  -     ISSN:  1462-0332     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Rheumatology, Hospital General Universitario Gregorio Marañón and Complutense University, Madrid, Department of Rheumatology, Instituto Poal, Barcelona, Department of Rheumatology, Hospital de Valdecilla, Santander, Department of Rheumatology, Hospital Universitario Infanta Sofía, Madrid, Department of Rheumatology, Hospital Moisès Broggi de Sant Joan Despí, Barcelona, Department of Rheumatology, Hospital Basurto, Bilbao, Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Department of Rheumatology, Hospital Universitario Infanta Leonor, Madrid, Spain, Department of Rheumatology, Sapienza Università di Roma, Rome, Italy, Department of Social Psychology and Methodology Faculty of Psychology, Autónoma University of Madrid and Department of Preventive Medicine and Public Health, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.
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