Document Detail


Automated noninvasive classification of renal cancer on multiphase CT.
MedLine Citation:
PMID:  21992388     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To explore the added value of the shape of renal lesions for classifying renal neoplasms. To investigate the potential of computer-aided analysis of contrast-enhanced computed-tomography (CT) to quantify and classify renal lesions.
METHODS: A computer-aided clinical tool based on adaptive level sets was employed to analyze 125 renal lesions from contrast-enhanced abdominal CT studies of 43 patients. There were 47 cysts and 78 neoplasms: 22 Von Hippel-Lindau (VHL), 16 Birt-Hogg-Dube (BHD), 19 hereditary papillary renal carcinomas (HPRC), and 21 hereditary leiomyomatosis and renal cell cancers (HLRCC). The technique quantified the three-dimensional size and enhancement of lesions. Intrapatient and interphase registration facilitated the study of lesion serial enhancement. The histograms of curvature-related features were used to classify the lesion types. The areas under the curve (AUC) were calculated for receiver operating characteristic curves.
RESULTS: Tumors were robustly segmented with 0.80 overlap (0.98 correlation) between manual and semi-automated quantifications. The method further identified morphological discrepancies between the types of lesions. The classification based on lesion appearance, enhancement and morphology between cysts and cancers showed AUC = 0.98; for BHD + VHL (solid cancers) vs. HPRC + HLRCC AUC = 0.99; for VHL vs. BHD AUC = 0.82; and for HPRC vs. HLRCC AUC = 0.84. All semi-automated classifications were statistically significant (p < 0.05) and superior to the analyses based solely on serial enhancement.
CONCLUSIONS: The computer-aided clinical tool allowed the accurate quantification of cystic, solid, and mixed renal tumors. Cancer types were classified into four categories using their shape and enhancement. Comprehensive imaging biomarkers of renal neoplasms on abdominal CT may facilitate their noninvasive classification, guide clinical management, and monitor responses to drugs or interventions.
Authors:
Marius George Linguraru; Shijun Wang; Furhawn Shah; Rabindra Gautam; James Peterson; W Marston Linehan; Ronald M Summers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Medical physics     Volume:  38     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  2011-12-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5738-46     Citation Subset:  IM    
Affiliation:
Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Algorithms
Area Under Curve
Automatic Data Processing / methods
Automation
Carcinoma, Papillary / diagnosis*,  radiography*
Female
Humans
Kidney Neoplasms / classification,  diagnosis*,  radiography*
Male
Middle Aged
ROC Curve
Radiographic Image Interpretation, Computer-Assisted
Reproducibility of Results
Tomography, X-Ray Computed / methods*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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