Document Detail

Automated neutrophil morphology and its utility in the assessment of neutrophil dysplasia.
MedLine Citation:
PMID:  17984041     Owner:  NLM     Status:  MEDLINE    
The automated hematology cell analyzer Coulter LH 750 (Beckman Coulter, Brea, CA, USA) uses a combination of 3 measurements-volume, conductivity, and scatter-to identify cells, but it could take advantage of these parameters to evaluate their morphologic changes. The neutrophil mean cell volume (MNEV), mean cell conductivity (MNEC), and mean cell scatter (MNES) were evaluated in 54 patients with myelodysplastic syndrome (MDS), 18 with chronic myelomonocytic leukemia (CMML), and 59 healthy controls. MNES and MNEC in the MDS group including all subtypes (World Health Organization classification) and in the CMML patients were significantly lower than the control group. MNES in MDS and CMML correlated well with the cytoplasmic hypogranularity evaluated by microscopic observation (P = .01). The value of MNES and MNEC as screening parameters in the neutrophil dysplasia evaluation showed, for this study, a sensitivity of 71.8% with a specificity of 86.4% (area under the curve [AUC], 0.817) and a cutoff of <139.3 for MNES and a sensitivity of 70.4% with a specificity of 76.3% (AUC, 0.752) and a cutoff of <150.9 for MNEC.
Amparo Miguel; Maite Orero; Ramon Simon; Rosa Collado; Pedro L Perez; Alejandro Pacios; Rosario Iglesias; Antonio Martinez; Felix Carbonell
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Laboratory hematology : official publication of the International Society for Laboratory Hematology     Volume:  13     ISSN:  1080-2924     ISO Abbreviation:  Lab Hematol     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-06     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615688     Medline TA:  Lab Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM    
Servicio de Hematologia, Consorcio Hospital General Universitario, Valencia, Spain.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Leukemia, Myelomonocytic, Chronic / blood*,  diagnosis,  pathology
Leukocyte Count / instrumentation*,  methods
Middle Aged
Myelodysplastic Syndromes / blood*,  diagnosis,  pathology
Neutrophils / classification*,  pathology*
Sensitivity and Specificity

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