| Automated morphologic evaluation of pulmonary arteries in primary pulmonary hypertension. | |
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MedLine Citation:
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PMID: 3804657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pulmonary wedge angiograms have been shown to reflect the severity of pulmonary vascular disease in congenital heart disease. Thirteen pulmonary wedge angiograms with a balloon occlusion catheter were performed in 11 adult patients (five normals and six with primary pulmonary hypertension [PPH]) and their features related to the resting pulmonary artery pressure (PAP). Individual cine frames from each study were selected and digitized with a computer-assisted operator-interactive program. By fitting densitometric profiles from the vessel segments, serial arterial cross-sectional diameters were calculated from mathematically derived points. There was a strong correlation between arterial taper (T, change in vessel caliber per unit axial length) and a power function of mean PAP with T = 0.304 X PAP-0.59, R = .91, P less than .001. These results demonstrate a correlation between an angiographically derived morphologic characteristic of the pulmonary vasculature (taper) and a hemodynamic parameter (PAP) in PPH. This offers a method to follow the course of the disease and the effects of drug therapy by assessing anatomic changes in the vessels. |
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Authors:
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L M Boxt; S Rich; R Fried; L La Follette; T Sandor; W B Hanlon; D P Harrington; L Reid |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 21 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-03-19 Completed Date: 1987-03-19 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 906-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Hypertension, Pulmonary / radiography* Image Processing, Computer-Assisted Pulmonary Artery / physiopathology, radiography* Pulmonary Wedge Pressure Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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