Document Detail

Automated method for calculation of a load-independent index of isovolumic pressure decay from left ventricular pressure data.
MedLine Citation:
PMID:  19964279     Owner:  NLM     Status:  MEDLINE    
Diastolic heart failure (DHF) is present in over 50% of hospitalized heart failure patients, and diastolic dysfunction is known to play a critical pathophysiologic role. Measurement of left-ventricular pressure (LVP) via catheterization is the gold standard for diastolic function (DF) evaluation, but current methods fail to fully capitalize on the complete information content of the pressure contour. We have previously demonstrated that a kinematic model of isovolumic pressure decay (IVPD), which accounts for restoring force (stiffness) and resistance (viscoelasticity/relaxation), provides mechanistic insight into IVPD physiology and provides an accurate fit to the recorded contour. Recently we derived a novel load-independent index of isovolumic pressure decay (LIIIVPD) involving IVPD kinematic model stiffness and resistance parameters. In this work we detail methods and provide guidelines by which LIIIVPD computation may be achieved in real-time from the pressure contour recorded during cardiac catheterization.
Leonid Shmuylovich; Sándor J Kovacs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-03-16     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3031-4     Citation Subset:  IM    
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MeSH Terms
Automatic Data Processing
Biomechanical Phenomena
Biomedical Engineering / methods
Blood Pressure
Heart Ventricles / physiopathology*
Models, Cardiovascular
Myocardial Contraction / physiology*
Signal Processing, Computer-Assisted*
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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