Document Detail

Automated measurement of spatial preference in the open field test with transmitted lighting.
MedLine Citation:
PMID:  18342949     Owner:  NLM     Status:  MEDLINE    
New modification of the open field was designed to improve automation of the test. The main innovations were: (1) transmitted lighting and (2) estimation of probability to find pixels associated with an animal in the selected region of arena as an objective index of spatial preference. Transmitted (inverted) lighting significantly ameliorated the contrast between an animal and arena and allowed to track white animals with similar efficacy as colored ones. Probability as a measure of preference of selected region was mathematically proved and experimentally verified. A good correlation between probability and classic indices of spatial preference (number of region entries and time spent therein) was shown. The algorithm of calculation of probability to find pixels associated with an animal in the selected region was implemented in the EthoStudio software. Significant interstrain differences in locomotion and the central zone preference (index of anxiety) were shown using the inverted lighting and the EthoStudio software in mice of six inbred strains. The effects of arena shape (circle or square) and a novel object presence in the center of arena on the open field behavior in mice were studied.
Alexander V Kulikov; Maria A Tikhonova; Victor A Kulikov
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-07
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  170     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Avenue Lavrentyev 10, Novosibirsk 630090, Russia.
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MeSH Terms
Behavior, Animal / physiology*
Mice, Inbred A
Mice, Inbred AKR
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Inbred DBA
Space Perception / physiology*
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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