Document Detail

Automated measurement of melanoma cross-sectional area.
MedLine Citation:
PMID:  9557784     Owner:  NLM     Status:  MEDLINE    
The object of this study was to evaluate the prognostic impact of a cross-sectional area measured in routinely stained slides of cutaneous melanoma using fully automated image analysis. Hematoxylin-eosin stained slides of 238 specimens of primary cutaneous melanoma with Clark levels III to V were evaluated by digital image analysis using color video images, a scanning stage, and autofocus equipment. The cross-sectional area was significantly related to metastasis-free survival. Lesions with a cross-sectional area < or = 12 mm2 showed a 2-year metastasis-free survival rate of 92+/-2% compared with 41+/-8% in lesions with a cross-sectional area > 12 mm2 (log rank test: z = 71, p < 0.0001). The same was true for overall survival (98+/-1% compared with 82+/-6%; z = 42.12, p < 0.0001). In multivariate analysis, the cross-sectional area seems to provide prognostic information in addition to that provided by Breslow's index. In cases with regression and in small melanomas with vertical growth, however, metastatic spread may occur in lesions with a small cross-sectional area. It was concluded that automated measurement of the cross-sectional area may be helpful in assessing prognosis in cutaneous melanoma.
J Smolle; A Okcu; R Hofmann-Wellenhof; E Pfaffenthaler; R Fink-Puches; E Richtig; H Kerl
Related Documents :
6361264 - A new, less toxic polymerization system for the embedding of soft tissues in glycol met...
2336734 - Quantitative energy-filtered image analysis in cytochemistry. i. morphometric analysis ...
23101604 - Advanced imaging and arthroscopic management of shoulder contracture after birth palsy.
8116884 - Three-dimensional reconstructions of the primary palate region in normal human embryos.
21552454 - Evaluation of a rotary laser body scanner for body volume and fat assessment.
15676554 - Ergonomics of manual harvesting.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  20     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-03     Completed Date:  1998-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Dermatology, University of Graz, Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Disease-Free Survival
Image Processing, Computer-Assisted*
Melanoma / diagnosis,  mortality,  pathology*
Middle Aged
Multivariate Analysis
Skin Neoplasms / diagnosis,  mortality,  pathology*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fibronectin and the extracellular matrix in the perforating disorders of the skin.
Next Document:  Estrogen and progesterone receptors in androgenic alopecia versus alopecia areata.