Document Detail

Automated interpretation of planar thallium-201-dipyridamole stress-redistribution scintigrams using artificial neural networks.
MedLine Citation:
PMID:  7989989     Owner:  NLM     Status:  MEDLINE    
To develop an automated image interpretation system of planar cardiac 201Tl dipyridamole stress/redistribution scintigrams, the authors used artificial neural networks that associate patterns of segmental myocardial thallium uptake with a diagnostic assessment about the presence, severity and localization of significant coronary artery disease. METHODS: Artificial neural networks were trained and evaluated using the results from segmental thallium analysis and either expert readings in 159 cases or coronary angiography in a subgroup of 81 patients. RESULTS: Based on receiver operating characteristics analysis, the sensitivity for the detection of significant coronary artery disease at a specificity of 90% was 51% compared with angiography and 72% compared with the human expert. For severity and localization of disease, two vascular territories assigned to the vascular bed of the left anterior descending (LAD) artery and to the territory subtended by the left circumflex artery and the right coronary artery together (CX/RCA) were included in the analysis. CONCLUSION: Artificial neural networks may be useful to develop automated computer-based image interpretation systems of 201Tl perfusion scintigrams. However, utilization of large training datasets appears to be a prerequisite to achieve adequate diagnostic performance.
G Porenta; G Dorffner; S Kundrat; P Petta; J Duit-Schedlmayer; H Sochor
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  35     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-01-06     Completed Date:  1995-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2041-7     Citation Subset:  IM    
Department of Cardiology, University of Vienna Medical School, Austria.
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MeSH Terms
Coronary Angiography
Coronary Disease / radiography,  radionuclide imaging*
Coronary Vessels / radionuclide imaging
Dipyridamole / diagnostic use*,  pharmacokinetics
Exercise Test*
Heart / radionuclide imaging*
Middle Aged
Neural Networks (Computer)*
Retrospective Studies
Thallium Radioisotopes / diagnostic use*,  pharmacokinetics
Tomography, Emission-Computed*
Reg. No./Substance:
0/Thallium Radioisotopes; 58-32-2/Dipyridamole
Comment In:
J Nucl Med. 1994 Dec;35(12):2048-9   [PMID:  7989990 ]

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