Document Detail


Automated carbohydrate synthesis to drive chemical glycomics.
MedLine Citation:
PMID:  12778696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This feature article describes the development of the first automated solid-phase oligosaccharide synthesizer. A series of chemical challenges had to be addressed to accomplish this breakthrough and provide rapid access to oligosaccharides of biological significance. Accelerated synthesis of glycoconjugates promises to greatly impact the emerging field of glycobiology. Chemical glycomics uses synthetic carbohydrates and analogs to study their role in recognition, signal transduction pathways and other events of fundamental biomedical significance and shapes up to become the next major wave in biomedical research. The automated synthesis of a novel malaria vaccine candidate is discussed to illustrate the medical potential of chemical glycomics.
Authors:
Peter H Seeberger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1359-7345     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2004-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1115-21     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. seeberg@mit.edu
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MeSH Terms
Descriptor/Qualifier:
Automation / methods*
Carbohydrate Sequence
Glycosylation
Humans
Malaria Vaccines / chemical synthesis
Molecular Sequence Data
Oligosaccharides / chemical synthesis*,  chemistry*
Chemical
Reg. No./Substance:
0/Malaria Vaccines; 0/Oligosaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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