| Automated assays for sVEGF R1 and PlGF as an aid in the diagnosis of preterm preeclampsia: a prospective clinical study. | |
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MedLine Citation:
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PMID: 19762001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to assess the utility of soluble vascular endothelial growth factor 1 (sVEGF R1) and placental growth factor (PlGF) levels in the clinical diagnosis of preeclampsia. STUDY DESIGN: Plasma was collected prospectively from 457 subjects (n = 409 without preeclampsia, n = 48 with preeclampsia) at 20-36 weeks' gestation. Automated immunoassays were used to measure free sVEGF R1 and free PlGF. RESULTS: Clinical sensitivities of 0.96 and specificities of 0.96 and 0.95 were calculated for sVEGF R1 and PlGF, respectively, for aiding in the diagnosis of preeclampsia. Among subjects with chronic hypertension, sVEGFR1 was dramatically elevated and PlGF decreased in those with superimposed preeclampsia (P < .001 for superimposed preeclampsia vs chronic hypertension for both biomarkers). The ratio of sVEGFR1/PlGF provided a better test to aid in the diagnosis of preeclampsia than either analyte alone (3% false positive rate). CONCLUSION: Free sVEGF R1 and PlGF were useful in differentiating women with preterm preeclampsia from normotensive and hypertensive subjects. |
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Authors:
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Shiraz Sunderji; Emanuel Gaziano; Donald Wothe; Linda C Rogers; Baha Sibai; S Ananth Karumanchi; Cheryl Hodges-Savola |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-09-17 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 202 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 40.e1-7 Citation Subset: AIM; IM |
Copyright Information:
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2010 Mosby, Inc. |
Affiliation:
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Department of Maternal-Fetal Medicine, The Toledo Hospital, OH 43606, USA. shiraz.sunderjimd@promedica.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Immunoassay / methods* Pre-Eclampsia / diagnosis* Pregnancy Pregnancy Proteins / blood* Prospective Studies ROC Curve Sensitivity and Specificity Vascular Endothelial Growth Factor Receptor-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Pregnancy Proteins; 144589-93-5/placenta growth factor; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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