Document Detail

Automated three-dimensional quantification of noncalcified coronary plaque from coronary CT angiography: comparison with intravascular US.
MedLine Citation:
PMID:  20829536     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the accuracy of a previously developed automated algorithm (AUTOPLAQ [APQ]) for rapid volumetric quantification of noncalcified and calcified plaque from coronary computed tomographic (CT) angiography in comparison with intravascular ultrasonography (US).
MATERIALS AND METHODS: This study was approved by the institutional review board and was HIPAA compliant; all patients provided written informed consent. APQ combines derived scan-specific attenuation threshold levels for lumen, plaque, and knowledge-based segmentation of coronary arteries for quantification of plaque components. APQ was validated with retrospective analysis of 22 coronary atherosclerotic plaques in 20 patients imaged with coronary CT angiography and intravascular US within 2 days of each other. Coronary CT angiographic data were acquired by using dual-source CT. For each patient, well-defined plaques without calcifications were selected, and plaque volume was measured with APQ and manual tracing at CT and with intravascular US. Measurements were compared with paired t test, correlation, and Bland-Altman analysis.
RESULTS: There was excellent correlation between noncalcified plaque volumes quantified with APQ and intravascular US (r = 0.94, P < .001), with no significant differences (P = .08). Mean plaque volume with intravascular US was 105.9 mm³ ± 83.5 (standard deviation) and with APQ was 116.6 mm³ ± 80.1. Mean plaque volume with manual tracing from CT was 100.8 mm³ ± 81.7 and with APQ was 116.6 mm³ ± 80.1, with excellent correlation (r = 0.92, P < .001) and no significant differences (P = .23).
CONCLUSION: Automated scan-specific threshold level-based quantification of plaque components from coronary CT angiography allows rapid, accurate measurement of noncalcified plaque volumes, compared with intravascular US, and requires a fraction of the time needed for manual analysis.
Damini Dey; Tiziano Schepis; Mohamed Marwan; Piotr J Slomka; Daniel S Berman; Stephan Achenbach
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  Radiology     Volume:  257     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-20     Completed Date:  2010-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  516-22     Citation Subset:  AIM; IM    
Copyright Information:
© RSNA, 2010.
Department of Imaging, Cedars-Sinai Medical Center, Cedars-Sinai Heart Institute, and David-Geffen School of Medicine, UCLA, 8700 Beverly Blvd, Taper Building A238, Los Angeles, CA 90048, USA.
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MeSH Terms
Contrast Media / diagnostic use
Coronary Angiography / methods*
Coronary Artery Disease / radiography*,  ultrasonography*
Coronary Vessels / ultrasonography
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional
Iopamidol / analogs & derivatives,  diagnostic use
Middle Aged
Retrospective Studies
Time Factors
Tomography, X-Ray Computed*
Ultrasonography, Interventional / methods*
Reg. No./Substance:
0/Contrast Media; 62883-00-5/Iopamidol; 78649-41-9/iomeprol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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