Document Detail

Automated Solid-Phase Synthesis of β-Mannuronic Acid Alginates.
MedLine Citation:
PMID:  22334421     Owner:  NLM     Status:  Publisher    
A big step towards routine: The title synthesis provides of mannuronic acid alginate fragments featuring up to 12 cis-mannosidic linkages, in multi-milligram quantities (see scheme; Bn=benzyl, Lev=levulinoyl). Mannuronic acid building blocks were used in a second-generation carbohydrate synthesizer to secure the stereoselective introduction of the β-mannosidic bonds in a fully automated fashion.
Marthe T C Walvoort; Hans van den Elst; Obadiah J Plante; Lenz Kröck; Peter H Seeberger; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-14
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Leiden Institute of Chemistry, Leiden University, P.O.Box 9502, 2300 RA Leiden (The Netherlands).
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