Document Detail


Automated Solid-Phase Synthesis of Hyaluronan Oligosaccharides.
MedLine Citation:
PMID:  22780913     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Well-defined fragments of hyaluronic acid (HA) have been obtained through a fully automated solid-phase oligosaccharide synthesis. Disaccharide building blocks, featuring a disarmed glucuronic acid donor moiety and a di-tert-butylsilylidene-protected glucosamine part, were used in the rapid and efficient assembly of HA fragments up to the pentadecamer level, equipped with a conjugation-ready anomeric allyl function.
Authors:
Marthe T C Walvoort; Anne Geert Volbeda; Niels R M Reintjens; Hans van den Elst; Obadiah J Plante; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Leiden Institute of Chemistry, Leiden University , P.O. Box 9502, 2300 RA Leiden, The Netherlands, and Ancora Pharmaceuticals , 1B Gill Street, Woburn, Massachusetts 01801, United States.
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