Document Detail


Automated segmentation of mouse brain images using multi-atlas multi-ROI deformation and label fusion.
MedLine Citation:
PMID:  23055043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We propose an automated multi-atlas and multi-ROI based segmentation method for both skull-stripping of mouse brain and the ROI-labeling of mouse brain structures from the three dimensional (3D) magnetic resonance images (MRI). Three main steps are involved in our method. First, a region of interest (ROI) guided warping algorithm is designed to register multi-atlas images to the subject space, by considering more on the matching of image contents around the ROI boundaries which are more important for ROI labeling. Then, a multi-atlas and multi-ROI based deformable segmentation method is adopted to refine the ROI labeling result by deforming each ROI surface via boundary recognizers (i.e., SVM classifiers) trained on local surface patches. Finally, a local-mutual-information (MI) based multi-label fusion technique is proposed for allowing the atlases with better local image similarity with the subject to have more contributions in label fusion. The experimental results show that our method works better than the conventional methods on both in vitro and in vivo mouse brain datasets.
Authors:
Jingxin Nie; Dinggang Shen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroinformatics     Volume:  11     ISSN:  1559-0089     ISO Abbreviation:  Neuroinformatics     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-17     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101142069     Medline TA:  Neuroinformatics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / anatomy & histology*
Image Interpretation, Computer-Assisted / methods*
Image Processing, Computer-Assisted / methods*
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Mice
Neuroimaging / methods
Support Vector Machines
Grant Support
ID/Acronym/Agency:
AG041721/AG/NIA NIH HHS; CA140413/CA/NCI NIH HHS; EB006733/EB/NIBIB NIH HHS; EB008374/EB/NIBIB NIH HHS; EB009634/EB/NIBIB NIH HHS; R01 AG041721/AG/NIA NIH HHS; R01 CA140413/CA/NCI NIH HHS; R01 EB006733/EB/NIBIB NIH HHS; R01 EB008374/EB/NIBIB NIH HHS; R01 EB009634/EB/NIBIB NIH HHS; RC1 MH088520/MH/NIMH NIH HHS
Comments/Corrections

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