Document Detail


Automated ROI-based brain parcellation analysis of frontal and temporal brain volumes in schizophrenia.
MedLine Citation:
PMID:  16949259     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structural MRI studies of schizophrenia have yielded a diversity of findings. To help characterize regional gray matter changes in schizophrenia, we used an automated region of interest (ROI)-based approach that targeted frontal and temporal regions in schizophrenia patients. The sample compromised 43 schizophrenia patients (21 chronic patients, 22 unmedicated first episode patients), 20 first episode non-schizophrenia psychosis patients and 47 comparison subjects. Automated regional volume measurement was performed in 22 ROIs, including frontal and temporal cortical subregions and hippocampus. Correlations between volume measures, duration of illness and clinical scores were evaluated. Chronic schizophrenia patients showed gray matter volume differences in left dorsolateral prefrontal cortex (DLPFC) and right supplementary motor area (SMA). First episode psychosis patients presented smaller right anterior cingulate cortex (ACC) and left DLPFC than comparison subjects. Disorganization scores and duration of illness correlated negatively with gray matter volume of DLPFC and SMA in chronic schizophrenia patients. Using an automated ROI-based method, we found volume reductions in lateral and medial frontal regions in both first episode and chronic schizophrenia. The automated ROI-based method can be used as a valid and efficient tool for quantification of regional gray matter volume in schizophrenia in multiple ROIs across the brains of large numbers of subjects.
Authors:
Pilar Lopez-Garcia; Howard J Aizenstein; Beth E Snitz; Ryan P Walter; Cameron S Carter
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-09-01
Journal Detail:
Title:  Psychiatry research     Volume:  147     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-12-07     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  153-61     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, School of Medicine, University of California, Davis, United States. plopezgarcia@unav.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Automatic Data Processing*
Chronic Disease
Female
Frontal Lobe / anatomy & histology*,  physiopathology*
Humans
Magnetic Resonance Imaging*
Prefrontal Cortex / anatomy & histology,  physiopathology
Schizophrenia / diagnosis*,  physiopathology*
Temporal Lobe / anatomy & histology*,  physiopathology*
Grant Support
ID/Acronym/Agency:
K02MH064190/MH/NIMH NIH HHS; R01MH66629/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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