Document Detail

Automated office blood pressure is associated with urine albumin excretion in hypertensive subjects.
MedLine Citation:
PMID:  22695505     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We aimed to investigate the association between automated office blood pressure (AOBP) readings and urine albumin excretion (UAE), and to assess if this association is as close as that between 24-h ambulatory blood pressure (ABP) and UAE. A strong association would suggest that AOBP may serve as an indicator of early renal impairment.
METHODS: In a sample of 162 hypertensives, we compared AOBP with ABP measurements and their associations with UAE in two consecutive 24-h urine collections measured by an immunoturbidimetric assay. Microalbuminuria was defined as UAE of 30-300 mg/24 h.
RESULTS: The age of the subjects was 53 ± 13 (mean ± s.d.) years. Twenty-two were microalbuminuric. In those, AOBP and 24-h ABP were higher than in the normoalbuminuric subjects: 152 ± 19 and 147 ± 20 vs. 138 ± 15 and 130 ± 11 mm Hg for systolic blood pressure (SBP), and 97 ± 15 and 92 ± 14 vs. 86 ± 10 and 82 ± 8 mm Hg for diastolic blood pressure (DBP) (P < 0.001). Correlations between AOBP and 24-h ABP with log-transformed urine albumin were 0.30 (P < 0.001) and 0.43 (P < 0.001) for SBP and 0.27 (P < 0.001) and 0.33 (P < 0.001) for DBP. Adjusting for age, sex, body mass index, and estimated glomerular filtration rate, both AOBP and 24-h ABP were independently associated with urine albumin (P < 0.001 for both associations). Receiver operating characteristics curve analysis showed a similar predictive ability for microalbuminuria for AOBP and for 24-h ABP (area under the curve: 0.819 (P < 0.001) for SBP, 0.836 (P < 0.001) for DBP vs. 0.830 (P < 0.001) for SBP and 0.845 (P < 0.001) for DBP).
CONCLUSIONS: In this study, microalbuminuria correlated similarly with high-quality AOBP and ABP readings, further supporting the use of AOBP in the clinical setting.
Emmanuel A Andreadis; Gerasimos D Agaliotis; Epameinondas T Angelopoulos; Athanasios P Tsakanikas; George N Kolyvas; George P Mousoulis
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Publication Detail:
Type:  Journal Article     Date:  2012-06-14
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-23     Completed Date:  2013-01-03     Revised Date:  2013-03-17    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  969-73     Citation Subset:  IM    
3rd Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece.
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MeSH Terms
Albuminuria / complications
Blood Pressure / physiology*
Cardiovascular Diseases / etiology
Hypertension / physiopathology*,  urine
Middle Aged
Comment In:
Am J Hypertens. 2013 Jan;26(1):3-4   [PMID:  23382320 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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