Document Detail

Automated detection of malaria-associated pseudoeosinophilia and abnormal WBC scattergram by the Sysmex XE-2100 hematology analyzer: a clinical study with 1,801 patients and real-time quantitative PCR analysis in vivax malaria-endemic area.
MedLine Citation:
PMID:  20207865     Owner:  NLM     Status:  MEDLINE    
Recently, the XE-2100 hematology analyzer was investigated in a rather small patient group; pseudoeosinophilia or abnormal white blood cell (WBC) scattergrams reported by this instrument were considered as significantly valuable diagnostic parameters in detecting vivax malaria. This study was conducted not only to assess the usefulness of pseudoeosinophilia or abnormal WBC scattergram in vivax malaria-endemic areas with large patient groups (N = 1,801) but also to investigate the correlation of parasitemia and platelet count with pseudoeosinophilia and abnormal WBC scattergrams. Of the 1,801 analyzed patients, 413 (22.9%) were found to have malaria by Wright-Giemsa stained blood smears. Overall, either pseudoeosinophilia or abnormal WBC scattergram was detected in 191 of 413 malaria patients and 4 of 1,388 patients without malaria (sensitivity = 46.2%, specificity = 99.7%). We suggest that clinical hematology laboratories using the XE-2100 analyzer should be aware of such specific parameters, even with the absence of a clinical request.
Jong-Ha Yoo; Jaewoo Song; Kyung-A Lee; Young-Kyu Sun; Young-Ah Kim; Tae Sung Park; Jong Rak Choi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  82     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-03-29     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412-4     Citation Subset:  AIM; IM    
Department of Laboratory Medicine, National Health Insurance Corporation, Ilsan Hospital, Goyang, Korea.
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MeSH Terms
Endemic Diseases
Eosinophilia / blood,  complications,  diagnosis
Hematologic Tests / instrumentation*,  methods
Leukocyte Count / instrumentation*,  methods
Malaria / complications*
Malaria, Vivax / blood,  complications*,  diagnosis
Polymerase Chain Reaction / methods*
Sensitivity and Specificity

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