| Automated detection of malaria-associated pseudoeosinophilia and abnormal WBC scattergram by the Sysmex XE-2100 hematology analyzer: a clinical study with 1,801 patients and real-time quantitative PCR analysis in vivax malaria-endemic area. | |
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MedLine Citation:
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PMID: 20207865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently, the XE-2100 hematology analyzer was investigated in a rather small patient group; pseudoeosinophilia or abnormal white blood cell (WBC) scattergrams reported by this instrument were considered as significantly valuable diagnostic parameters in detecting vivax malaria. This study was conducted not only to assess the usefulness of pseudoeosinophilia or abnormal WBC scattergram in vivax malaria-endemic areas with large patient groups (N = 1,801) but also to investigate the correlation of parasitemia and platelet count with pseudoeosinophilia and abnormal WBC scattergrams. Of the 1,801 analyzed patients, 413 (22.9%) were found to have malaria by Wright-Giemsa stained blood smears. Overall, either pseudoeosinophilia or abnormal WBC scattergram was detected in 191 of 413 malaria patients and 4 of 1,388 patients without malaria (sensitivity = 46.2%, specificity = 99.7%). We suggest that clinical hematology laboratories using the XE-2100 analyzer should be aware of such specific parameters, even with the absence of a clinical request. |
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Authors:
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Jong-Ha Yoo; Jaewoo Song; Kyung-A Lee; Young-Kyu Sun; Young-Ah Kim; Tae Sung Park; Jong Rak Choi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 82 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2010-03-29 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 412-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Laboratory Medicine, National Health Insurance Corporation, Ilsan Hospital, Goyang, Korea. jhyoo92@nhimc.or.kr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Automation Endemic Diseases Eosinophilia / blood, complications, diagnosis Hematologic Tests / instrumentation*, methods Humans Leukocyte Count / instrumentation*, methods Malaria / complications* Malaria, Vivax / blood, complications*, diagnosis Polymerase Chain Reaction / methods* Sensitivity and Specificity |
| Comments/Corrections | |
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