Document Detail

Automated border detection for assessing the mechanical properties of the carotid arteries: comparison with carotid intima-media thickness.
MedLine Citation:
PMID:  20202793     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although carotid intima-media thickness (CIMT) assesses the structural properties of the carotid artery, it does not assess the mechanical properties of the vessel. METHODS: The carotid arteries of 71 adult patients were evaluated with CIMT, and automated border detection computed vessel stiffness, compliance, elasticity, and distensibility. RESULTS: CIMT and mechanical properties were differentially affected by traditional cardiac risk factors, with age dominating for CIMT, and age, diabetes, and smoking dominating for mechanical variables. There was a moderate linear correlation between CIMT and the distensibility coefficient (r = -0.54), but there were weak associations with other parameters of dynamic vessel function. When patients were separated into risk groups, the mechanical vascular parameters' classification frequently differed from the CIMT classification. This was particularly notable for patients with intermediate CIMT values, who were reclassified as low or high risk by mechanical parameters 45% of the time. CONCLUSION: We found that it is feasible to assess the cross-sectional area of the carotid artery using automatic border detection, which allows a novel method of determining carotid mechanical properties. These functional characteristics are often discordant with CIMT, suggesting that mechanical properties may be an important adjunct to the CIMT when evaluating the carotid artery.
Michael Luc; Tamar Polonsky; Georgeanne Lammertin; Kirk Spencer
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Publication Detail:
Type:  Journal Article     Date:  2010-03-03
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  23     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  567-72     Citation Subset:  IM    
Copyright Information:
2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.
University of Chicago, Chicago, Illinois 60637, USA.
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MeSH Terms
Carotid Arteries / physiology*,  ultrasonography*
Echocardiography / methods*
Elastic Modulus / physiology
Elasticity Imaging Techniques / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods
Middle Aged
Pattern Recognition, Automated / methods*
Reproducibility of Results
Sensitivity and Specificity
Shear Strength / physiology
Tunica Intima / physiology,  ultrasonography
Tunica Media / physiology,  ultrasonography

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