| Autologous stem cell transplantation using MEAM regimen for relapsed AIDS-related lymphoma patients who received highly active anti-retroviral therapy: a report of three cases. | |
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MedLine Citation:
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PMID: 19145056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIDS-related lymphoma (ARL) is a serious complication of HIV infection. We performed MEAM (MCNU + etoposide + cytarabine + L-PAM) regimen with autologous stem cell transplantation (ASCT) for three patients with refractory or relapsed ARL. All three patients had been treated with highly active anti-retroviral therapy (HAART) during the course of the treatment regimen and ASCT. The regimen was well tolerable, and no uncontrollable infection was noted. All patients are still alive and maintain complete remission at 24, 20 and 9 months after transplantation. ASCT using MEAM regimen as a conditioning regimen was feasible for our patients with refractory or relapsed ARL. |
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Authors:
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Kimihito C Kawabata; Shotaro Hagiwara; Ayako Takenouchi; Akira Tanimura; Junko Tanuma; Natsuo Tachikawa; Akiyoshi Miwa; Shinichi Oka |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-01-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 48 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-15 Completed Date: 2009-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 111-4 Citation Subset: IM |
Affiliation:
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Division of Hematology, Internal Medicine, International Medical Center of JAPAN, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antineoplastic Combined Chemotherapy Protocols / administration & dosage, adverse effects Antiretroviral Therapy, Highly Active Cytarabine / administration & dosage Etoposide / administration & dosage Female HIV Infections / drug therapy Hematopoietic Stem Cell Transplantation* Humans Lymphoma, AIDS-Related / therapy* Male Melphalan / administration & dosage Nitrosourea Compounds / administration & dosage Recurrence Salvage Therapy Transplantation Conditioning / adverse effects, methods* Transplantation, Autologous |
| Chemical | |
Reg. No./Substance:
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0/Nitrosourea Compounds; 147-94-4/Cytarabine; 148-82-3/Melphalan; 33419-42-0/Etoposide; 58994-96-0/ranimustine |
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