Document Detail

Autologous serum for the treatment of corneal epithelial abrasions in diabetic patients undergoing vitrectomy.
MedLine Citation:
PMID:  16876497     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare the effect of autologous serum versus hyaluronic acid for the treatment of epithelial corneal lesions in patients such as diabetics with reduced wound healing. DESIGN: Prospective, randomized, masked clinical trial. METHODS: Diabetic patients undergoing pars plana vitrectomy mostly combined with cataract extraction and intraocular lens (IOL) implantation who received corneal abrasion for better intraoperative visualization were included in this study. A standardized 8-mm diameter corneal abrasion was performed. Patients were randomized into one group treated with hourly application of autologous serum and another treated with hyaluronic acid drops (Vislube). Besides the time necessary for closure of the corneal epithelium other parameters such as patients' age, gender, duration of surgery, history of diabetes, and current HbA1C were evaluated. RESULTS: A total of 23 patients were enrolled (15 men, eight women); the autologous serum group consisted of 13 patients, the hyaluronic acid (Vislube) group consisted of 10 patients. Patients' mean age was 64.8 years; mean duration of diabetes was 19.4 years. On average, the operation lasted 145 minutes. Mean epithelialization time was 7.1 days in the hyaluronic acid group. In the autologous serum group, epithelium healed after a mean of 4.3 days. Mann-Whitney U test for statistical analysis showed a significant difference of epithelial closure time between both groups (P < .05); therefore, the study was stopped after treatment of 23 patients. CONCLUSIONS: It appears that autologous serum leads to a much faster closure of corneal epithelial wounds after abrasion compared with artificial tears.
Stephan D Schulze; Walter Sekundo; Peter Kroll
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  142     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  AIM; IM    
Department of Ophthalmology, University Hospital Giessen, Giessen, and Marburg, Location Marburg, Philipps University Marburg, Marburg, Germany.
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MeSH Terms
Cataract Extraction
Diabetic Retinopathy / surgery*
Double-Blind Method
Epithelium, Corneal / injuries*
Eye Injuries / etiology,  therapy*
Hemoglobin A, Glycosylated / analysis
Hyaluronic Acid / administration & dosage
Lens Implantation, Intraocular
Middle Aged
Ophthalmic Solutions / administration & dosage
Prospective Studies
Vitrectomy / adverse effects*
Vitreoretinopathy, Proliferative / surgery
Wound Healing / drug effects*
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Ophthalmic Solutions; 9004-61-9/Hyaluronic Acid
Comment In:
Am J Ophthalmol. 2006 Aug;142(2):316-7   [PMID:  16876515 ]

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