Document Detail

Autologous serum skin test reactivity and basophil histamine release test in patients with nasal polyposis: preliminary results.
MedLine Citation:
PMID:  20646361     Owner:  NLM     Status:  MEDLINE    
An eosinophilic inflammatory process is generally observed in patients suffering from nasal polyposis (NP), however its onset has not yet been defined. It has been suggested that immune activation of inflammatory cells may be the cause. The aim of this study is to verify whether autoantibodies and/or histamine-releasing factors are present in the serum of patients suffering from NP. In fact, we assume that autoantibodies and/or histamine-releasing factors, as already demonstrated in chronic idiopathic urticaria and asthma, may be involved in the pathogenesis of NP. In this case-control analytical study 40 patients with NP and 27 control subjects underwent the in vivo autologous serum skin test (ASST). The sera from 6 patients suffering from NP and 9 control group subjects, who had all been previously studied and randomly selected, underwent basophil histamine release assay from normal donor as a pilot study. The ASST showed positive results in 55% of patients suffering from NP versus 8% of the control group (p= .00006), the basophil histamine release test (BHRT) turned out positive in all patients tested and in 11% of the control group. We found a weak positive correlation between the percentage of histamine release and the wheal diameter. ASST reactivity is very frequent in patients suffering from NP, thus suggesting the presence of histamine-releasing factors in the blood stream. The BHRT was positive in the serum of all patients, thus suggesting the presence of anti-FcepsilonRI, anti-IgE autoantibodies and/or other histamine-releasing factors, the presence of which can play a role in triggering and maintaining the eosinophilic inflammatory process in NP.
G Zambetti; A Ciofalo; P Soldo; M Fusconi; R Romeo; A Greco; G Altissimi; G F Macri; C Marinelli; G Pagliuca; M De Vincentiis
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  23     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  641-7     Citation Subset:  IM    
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MeSH Terms
Autoantibodies / blood
Basophils / secretion*
Case-Control Studies
Histamine Release*
Middle Aged
Nasal Polyps / immunology*,  metabolism
Serum / immunology*
Skin Tests*
Reg. No./Substance:

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