Document Detail

Autologous retinal pigment epithelium-choroid sheet transplantation in age related macular degeneration: morphological and functional results.
MedLine Citation:
PMID:  17035275     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the outcome of autologous retinal pigment epithelium (RPE)-choroid sheet transplantation after removal of a subfoveal choroidal neovascularisation (CNV) in patients with age related macular degeneration (AMD). METHODS: RPE-choroid sheet transplantation was performed in 10 consecutive patients with exudative AMD (n = 9) or geographic atrophy (n = 1). After CNV extraction, an autologous RPE-choroid patch was translocated from the midperiphery under the macula. Follow-up was between 6 and 12 months. Visual acuity testing and microperimetry (Nidek-MP1) as well as autofluorescence, fluorescein and indocyanine green (ICG) angiography were performed and the data were analysed retrospectively. RESULTS: Visual acuity (logarithm of minimum angel of resolution) before operation ranged from 0.7 to 1.8 (mean 1.37) and after operation from 0.4 to 1.6 (mean 1.24). Visual acuity after operation improved in seven patients (by a mean of 0.26), remained stable in one patient and decreased in two patients. Microperimetry showed light sensitivity and fixation on the sheet in five cases. ICG angiography demonstrated perfusion through the RPE-choroid graft in nine patients. Postoperative complications included retinal detachment (n = 1) and epiretinal membrane formation (n = 2). The patient with geographic atrophy developed a CNV after surgery. CONCLUSIONS: Autologous RPE-choroid sheet transplantation is feasible and a comparatively safe procedure. Microperimetry showed fixation and light perception over the graft with a moderate increase in mean visual acuity.
Felix Treumer; Arnd Bunse; Carsten Klatt; Johann Roider
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2006-10-11
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  91     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-03-27     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  IM    
Department of Ophthalmology, University of Schleswig-Holstein, Campus Kiel, Hegewischstr, 2, 24105 Kiel, Germany.
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MeSH Terms
Aged, 80 and over
Choroid / blood supply,  transplantation*
Choroidal Neovascularization / physiopathology,  surgery
Epidemiologic Methods
Epiretinal Membrane / etiology
Macular Degeneration / physiopathology,  surgery*
Middle Aged
Pigment Epithelium of Eye / transplantation*
Postoperative Complications
Retinal Detachment / etiology
Treatment Outcome
Visual Acuity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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