Document Detail

Autologous platelet gel for tissue regeneration in degenerative disorders of the knee.
MedLine Citation:
PMID:  22044954     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The refinement of the use of platelet-derived growth factors that has occurred over the last decade has led to a broadening of the fields of use, in particular for new treatments in orthopaedics aimed at improving tissue regeneration.
MATERIALS AND METHODS: Twenty-seven patients, aged between 18 and 81 years, with a diagnosis of degenerative joint disease lasting for more than 1 year were treated. The patients were divided into two groups, one with arthritis of the knee, the other with degenerative cartilage disease of the knee. Both groups were treated with a therapeutic protocol consisting of a cycle of three infiltrations of platelet-rich plasma at weekly intervals.The extemporaneous preparation was made from a sample of about 8 mL of venous whole blood collected into a specific Fibrin Polymer 2 test-tube from RegenLab(®) and centrifuged before addition of calcium gluconate.During the initial pre-treatment evaluation, specific questionnaires were administered, the Numerical Rating Scale (NRS) for subjective measurement of pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); these assessments were repeated 7 days after the end of the treatment and at 6 months during the follow-up.
RESULTS: The parameters evaluated improved in both groups after treatment and there was a further improvement after 6 months of follow-up; furthermore, there was a substantial decrease in pain right after the first infiltration.
DISCUSSION: The patients were treated on an out-patient basis by a specifically created multidisciplinary team comprising a transfusion specialist, an orthopaedist and a radiologist, who collaborate in a symbiotic manner. The out-patient protocol exploits the regenerative properties of platelet-rich plasma, which is a low cost treatment; in practice, a diagnostic-therapeutic programme of lower intensity, but of high technical and professional quality is created. The strategy also reduces both the number of hospital services and the pharmacological support required, thereby optimising the use of health care resources.
Marcello Napolitano; Saverio Matera; Marcello Bossio; Antonio Crescibene; Enrico Costabile; Joan Almolla; Hesham Almolla; Francesco Togo; Casimiro Giannuzzi; Giampiero Guido
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Publication Detail:
Type:  Journal Article     Date:  2011-10-25
Journal Detail:
Title:  Blood transfusion = Trasfusione del sangue     Volume:  10     ISSN:  1723-2007     ISO Abbreviation:  Blood Transfus     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-05-14     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101237479     Medline TA:  Blood Transfus     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  IM    
Immunohaematology and Transfusion Medicine Unit, Cosenza Hospital, Cosenza, Italy.
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MeSH Terms
Aged, 80 and over
Arthritis / pathology,  therapy*
Blood Platelets*
Calcium Gluconate / administration & dosage*
Cartilage Diseases / pathology,  therapy*
Gels / administration & dosage*
Knee Joint*
Middle Aged
Regenerative Medicine / methods*
Reg. No./Substance:
0/Gels; 299-28-5/Calcium Gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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