Document Detail


Autologous peripheral blood stem cell transplantation in a patient with chronic autoimmune thrombocytopenia.
MedLine Citation:
PMID:  9359502     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunoablation by high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) is one approach currently under discussion for the treatment and possible cure of patients with severe autoimmune diseases. Chronic immune thrombocytopenic purpura (ITP) can be refractory to current therapies and in severe cases may constitute a life-threatening condition. We performed autologous PBSCT with T-cell depletion in a patient with severe chronic ITP but observed no effect on platelet levels. This contrasts with a recent report where complete remission was induced by a similar regimen in two patients with ITP Further studies will be necessary to identify subgroups of patients who might benefit from this form of therapy.
Authors:
R C Skoda; A Tichelli; A Tyndall; T Hoffmann; S Gillessen; A Gratwohl
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of haematology     Volume:  99     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  56-7     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University Hospital Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autoimmune Diseases / therapy*
Hematopoietic Stem Cell Transplantation / methods*
Humans
Thrombocytopenia / therapy*
Transplantation, Autologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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