Document Detail


Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs.
MedLine Citation:
PMID:  21392047     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Suaid FF, Ribeiro FV, Rodrigues TL, Silvério KG, Carvalho MD, Nociti Jr. FH, Casati MZ, Sallum EA: Autologous periodontal ligament cells in the treatment of class II furcation defects: a study in dogs. J Clin Periodontol 2011; doi: 10.1111/j.1600-051X.2010.01715.x ABSTRACT: Aim: The goal of this study was to histologically investigate the use of periodontal ligament cells (PDL cells) in tissue engineering to regenerate class II furcation defects. Material and Methods: PDL cells were obtained from the mandibular tooth extracted from each dog (seven), cultured in vitro and phenotypically characterized with regard to their biological properties. Following, bilateral class II furcation lesions were created at maxillary 3rd premolars and were randomly assigned to the test group [PDL cells+guided tissue regeneration (GTR)] or the control group (GTR). After 3 months, the animals were euthanized to evaluate the histometric parameters. Results: In vitro, PDL cells were able to promote mineral nodule formation and to express bone sialoprotein, type I collagen and alkaline phosphatase. Histometrically, data analysis demonstrated that the cell-treated group presented a superior length of new cementum (6.00 ± 1.50 and 8.08 ± 1.08 mm), a greater extension of periodontal regeneration (3.94 ± 1.20 and 7.28 ± 1.00 mm), a lower formation of connective tissue/epithelium (2.15 ± 1.92 and 0.60 ± 0.99 mm), a larger area of new bone (7.01 ± 0.61 and 9.02 ± 2.30 mm(2) ) and a smaller area of connective tissue/epithelium (5.90 ± 1.67 and 4.22 ± 0.95 mm(2) ), when compared with control group. Conclusion: PDL cells in association with GTR may significantly promote periodontal regeneration in class II furcation defects in dog.
Authors:
Fabricia Ferreira Suaid; Fernanda Vieira Ribeiro; Thaisângela L Rodrigues; Karina Gonzales Silvério; Marcelo Diniz Carvalho; Francisco Humberto Nociti; Marcio Zaffalon Casati; Enilson Antônio Sallum
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-11
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  -     ISSN:  1600-051X     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, State University of Campinas, São Paulo, Brazil Department of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Manaus, State University of Amazonas, Amazonas, Brazil.
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