Document Detail

Autologous chondrocyte implantation for traumatic large cartilage defect.
MedLine Citation:
PMID:  17710989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors report the immediate result (6 months) after Autologous Chondrocyte Implantation (ACI) in clinical and anatomic result with MRI. This is the first report ofACI that provides chondrocyte cells from a domestic lab. MATERIAL AND METHOD: ACI was done in a two-stage procedure, first stage via arthroscope to harvest cartilage and detect pathology. The authors found deep cartilage defect at grade 4 according ICRS, area 2.5 cm2 and near total meniscus tear. Meniscal repair and cartilage shaving were done. Harvesting 300 mg of cartilage was done in this stage. Four weeks later, the secondACl was done. Lateral para-patellar was used. Periosteum was used as chondrocyte suspension and by suture to the healthy cartilage, using prolene interrupted suture in conjunction with fibrin glue to seal the pocket after injecting the cell. Range of motion exercise started on day 2, assisted with continuous passive motion machine. Running and jumping were restricted for 9 months. RESULTS: No complication was found, full range of motion and walking was done at 7-8 weeks post operative. Visual analogue scale improved from 3 points to 0 point. MRI shows evidence of 100% filling of the repair tissue in defect site associated with hypertrophy of the repair tissue above chondral surface. CONCLUSION: Immediate result of ACI shows improvement in clinical and anatomic that present with MRI. Further follow up and case series is needed
Cholawish Chanlalit; Channarong Kasemkijwattanamd; Vithaya Varavit
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  90     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-09-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1435-42     Citation Subset:  IM    
Department of Orthopedics, Faculty of Medicine, Srinakharinvirot University, Nakhon Nayok 26120, Thailand.
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MeSH Terms
Cartilage, Articular / pathology,  surgery*
Chondrocytes / transplantation*
Knee Injuries / surgery*
Magnetic Resonance Imaging
Transplantation, Autologous*

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