Document Detail


Autologous bone marrow transplantation and hyperbaric oxygen therapy for patients with thromboangiitis obliterans.
MedLine Citation:
PMID:  17652224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many patients suffering from severe ischemic limb disease inevitably experience amputation, despite intensive therapies. Sympathectomy and hyperbaric oxygen therapy are optional therapies for patients with peripheral circulation disorders. Recently, several clinical studies have established that implantation of bone marrow-mononuclear cells into ischemic limbs increases collateral vessel formation. In the present study, autologous implantation of bone marrow-mononuclear cells was prescribed to 7 patients with ischemic limbs because of peripheral arterial disease. Although the extent of the improvement was not consistent among the 7 cases, all of the patients experienced some improvement in their symptoms. Transcutaneous oxygen partial pressure measured in a hyperbaric chamber increased in 5 patients. No side effects were observed. In conclusion, combined use of autologous bone marrow transplantation and hyperbaric oxygen therapy may be safe and effective for achievement of therapeutic angiogenesis.
Authors:
Shigeru Saito; Koichi Nishikawa; Hideaki Obata; Fumio Goto
Related Documents :
15322424 - Molecular detection of dopamine decarboxylase expression by means of reverse transcript...
3838794 - Parathyroid function and vitamin d status in patients with bone metastases of prostatic...
23059804 - Raising awareness about chronic intestinal pseudo-obstruction (cipo): a case report s...
24954324 - Correlation between soluble triggering receptor expressed on myeloid cells-1 and endosc...
6239524 - Successive effects of a vagolitic and a betadrenergic in the differential diagnosis of ...
22425694 - Intact fibroblast growth factor 23 levels predict incident cardiovascular event before ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-24
Journal Detail:
Title:  Angiology     Volume:  58     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2007 Aug-Sep
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan. shigerus@showa.gunma -u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Angiography
Bone Marrow Transplantation / methods*
Exercise Test
Female
Follow-Up Studies
Humans
Hyperbaric Oxygenation / methods*
Male
Middle Aged
Oximetry
Plethysmography
Thromboangiitis Obliterans / blood,  diagnosis,  therapy*
Transplantation, Autologous
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of slow coronary flow on P-wave duration and dispersion.
Next Document:  Increased high sensitive CRP level and its significance in pathogenesis of slow coronary flow.