Document Detail

Autologous bone marrow transplantation and hyperbaric oxygen therapy for patients with thromboangiitis obliterans.
MedLine Citation:
PMID:  17652224     Owner:  NLM     Status:  MEDLINE    
Many patients suffering from severe ischemic limb disease inevitably experience amputation, despite intensive therapies. Sympathectomy and hyperbaric oxygen therapy are optional therapies for patients with peripheral circulation disorders. Recently, several clinical studies have established that implantation of bone marrow-mononuclear cells into ischemic limbs increases collateral vessel formation. In the present study, autologous implantation of bone marrow-mononuclear cells was prescribed to 7 patients with ischemic limbs because of peripheral arterial disease. Although the extent of the improvement was not consistent among the 7 cases, all of the patients experienced some improvement in their symptoms. Transcutaneous oxygen partial pressure measured in a hyperbaric chamber increased in 5 patients. No side effects were observed. In conclusion, combined use of autologous bone marrow transplantation and hyperbaric oxygen therapy may be safe and effective for achievement of therapeutic angiogenesis.
Shigeru Saito; Koichi Nishikawa; Hideaki Obata; Fumio Goto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-24
Journal Detail:
Title:  Angiology     Volume:  58     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:    2007 Aug-Sep
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-34     Citation Subset:  IM    
Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan. shigerus@showa.gunma
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MeSH Terms
Bone Marrow Transplantation / methods*
Exercise Test
Follow-Up Studies
Hyperbaric Oxygenation / methods*
Middle Aged
Thromboangiitis Obliterans / blood,  diagnosis,  therapy*
Transplantation, Autologous
Treatment Outcome

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