| Autologous bone marrow transplantation and hyperbaric oxygen therapy for patients with thromboangiitis obliterans. | |
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MedLine Citation:
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PMID: 17652224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many patients suffering from severe ischemic limb disease inevitably experience amputation, despite intensive therapies. Sympathectomy and hyperbaric oxygen therapy are optional therapies for patients with peripheral circulation disorders. Recently, several clinical studies have established that implantation of bone marrow-mononuclear cells into ischemic limbs increases collateral vessel formation. In the present study, autologous implantation of bone marrow-mononuclear cells was prescribed to 7 patients with ischemic limbs because of peripheral arterial disease. Although the extent of the improvement was not consistent among the 7 cases, all of the patients experienced some improvement in their symptoms. Transcutaneous oxygen partial pressure measured in a hyperbaric chamber increased in 5 patients. No side effects were observed. In conclusion, combined use of autologous bone marrow transplantation and hyperbaric oxygen therapy may be safe and effective for achievement of therapeutic angiogenesis. |
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Authors:
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Shigeru Saito; Koichi Nishikawa; Hideaki Obata; Fumio Goto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-24 |
Journal Detail:
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Title: Angiology Volume: 58 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 2007 Aug-Sep |
Date Detail:
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Created Date: 2007-09-18 Completed Date: 2007-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: United States |
Other Details:
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Languages: eng Pagination: 429-34 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan. shigerus@showa.gunma -u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angiography Bone Marrow Transplantation / methods* Exercise Test Female Follow-Up Studies Humans Hyperbaric Oxygenation / methods* Male Middle Aged Oximetry Plethysmography Thromboangiitis Obliterans / blood, diagnosis, therapy* Transplantation, Autologous Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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