Document Detail


Autologous bone marrow transplantation for acute myeloid leukemia following in vitro treatment with neuraminidase and monoclonal antibodies.
MedLine Citation:
PMID:  1982228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although monoclonal antibodies (MoAbs) to CD15, especially PM-81, react with leukemic blasts from the majority of patients with acute myeloid leukemia (AML), a small subset of patients have cells that are CD15 negative or dim. We determined previously that neuraminidase will increase the reactivity of PM-81 with AML blasts, as well as blasts from many patients with acute lymphoblastic leukemia (ALL). In this report, we describe the laboratory results and clinical course of the first patient with AML whose harvested bone marrow was treated with neuraminidase prior to MoAbs and complement treatment. Neuraminidase increased the percentage of the patient's leukemia cells that reacted with PM-81 from 18% to 90% and more than doubled the percentage of AML blasts that were lysed by PM-81 and complement. The patient suffered no acute toxicity, engrafted rapidly, and was transfusion independent by day 21 post-ABMT. This report demonstrates the probable safety and efficacy of pretreatment of bone marrow with neuraminidase, and increases the number of patients with AML or ALL who may benefit from ABMT using marrow purging with MoAb to CD15.
Authors:
E D Ball; J J Vredenburgh; L E Mills; G G Cornwell; L Schwarz; A L Howell; K Troy
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  6     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-05-20     Completed Date:  1991-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
Affiliation:
Department of Medicine, Dartmouth Medical School, Hanover, NH 03856.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antibodies, Monoclonal / immunology,  therapeutic use*
Antigens, CD15
Antigens, Differentiation / immunology
Bone Marrow / drug effects,  immunology
Bone Marrow Transplantation*
Complement System Proteins / therapeutic use
Humans
Leukemia, Myeloid / drug therapy*,  immunology,  surgery
Male
Middle Aged
Neuraminidase / therapeutic use*
Transplantation, Autologous
Grant Support
ID/Acronym/Agency:
CA 31888/CA/NCI NIH HHS; CA 37868/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD15; 0/Antigens, Differentiation; 9007-36-7/Complement System Proteins; EC 3.2.1.18/Neuraminidase

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