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Autoimmunity in the pathogenesis of hypertension.
MedLine Citation:
PMID:  24247285     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypertension affects more than one-third of the adult population of the world. However, the cause of high blood pressure is unknown in the vast majority of patients, classified as patients with essential hypertension. Evidence accumulated over the past decade supports the participation of inflammation in the development of experimental hypertension. Investigations have also demonstrated that immune reactivity to overexpressed heat shock protein 70 (HSP70) is involved in the pathogenesis of salt-induced hypertension. This article reviews, first, the role of T cell-induced inflammation in the arteries, kidney and central nervous system in hypertension and the amelioration of hypertension induced by regulatory T cells. Second, experiments showing that autoimmunity directed to HSP70 in the kidney impairs the pressure natriuresis relationship and has a pivotal role in the pathogenesis of salt sensitive hypertension. Finally, we highlight the clinical evidence that supports the participation of autoimmunity in essential hypertension.
Authors:
Bernardo Rodríguez-Iturbe; Héctor Pons; Yasmir Quiroz; Miguel A Lanaspa; Richard J Johnson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-19
Journal Detail:
Title:  Nature reviews. Nephrology     Volume:  -     ISSN:  1759-507X     ISO Abbreviation:  Nat Rev Nephrol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500081     Medline TA:  Nat Rev Nephrol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Renal Service, Hospital Universitario and Laboratorio de Inmunobiología, Instituto Venezolano de Investigaciones Científicas (IVIC)-Zulia, Hospital Universitario de Maracaibo, Ave Goajira s/n, Maracaibo, Estado Zulia 4001-A, Venezuela.
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