| Autoimmunity-driven enzymatic remodeling of the dermal-epidermal junction in bullous pemphigoid and dermatitis herpetiformis. | |
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MedLine Citation:
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PMID: 21916544 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pathogenesis of blister formation in bullous pemphigoid (BP) and dermatitis herpetiformis (DH) is associated with destruction of numerous components of the dermal-epidermal junction. Proteolytic enzymes (PE) are involved in a multitude of physiological reactions and may have impact on the epidermal-dermal integrity. Involvement of various PE in inflammation and blister formation in BP and DH is intensively investigated using both morphologic and functional approaches, particularly in BP. The development into the full-blown stage in BP and DH may be caused by an impairment of the human Fc receptor regulatory system that may cause the inefficiently controlled activation of inflammatory cells and subsequent secretion of various proteases. |
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Authors:
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Justyna Gornowicz-Porowska; Monika Bowszyc-Dmochowska; Marian Dmochowski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-14 |
Journal Detail:
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Title: Autoimmunity Volume: - ISSN: 1607-842X ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900070 Medline TA: Autoimmunity Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences , Poznan , Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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