| Autoimmune thyroiditis in a child with steroid-dependent nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 18461358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Autoimmune thyroiditis is rarely described in association with nephrotic syndrome. Herein we report a girl who developed autoimmune thyroiditis insidiously during the course of minimal change nephrotic syndrome. She was steroid-sensitive, but developed severe steroid dependency and did not respond to cyclophosphamide therapy. She went into stable remission with levamisole. Five months after introduction of levamisole a mild goiter was found on systematic examination at school. The diagnosis of autoimmune thyroiditis was established with typical ultrasound appearance of the thyroid gland along with significant titers of antithyroid antibodies. It is very unlikely that levamisole was responsible for thyroiditis because experimental animal administration of high doses of levamisole inhibited lymphocyte infiltration of the thyroid. Since levamisole has had a beneficial effect on the nephrotic syndrome in our patient we decided to continue the treatment. She has been receiving levamisole for 3 years, and no adverse effects have been observed during the treatment period. |
| | |
Authors:
|
Velibor Tasic; Meri Angjeleska; Nadica Ristoska-Bojkovska; Gordana Petrusevska; Zoran Gucev |
Related Documents
:
|
10074608 - Chronic lymphocytic leukemia-associated membranous glomerulopathy: remission with fluda... 3354608 - Rett syndrome: abnormal membrane-bound lamellated inclusions in neurons and oligodendro... 662798 - Partial lipodystrophy with nephrotic syndrome. 16175948 - Nephrotic syndrome preceding hodgkin's lymphoma by 13 months. 9001808 - Cofs syndrome with familial 1;16 translocation. 19934148 - Aortic dissection in a case of turner's syndrome. |
Publication Detail:
|
Type: Case Reports; Journal Article Date: 2008-05-07 |
Journal Detail:
|
Title: European journal of pediatrics Volume: 168 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2008-12-19 Completed Date: 2009-03-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
|
Languages: eng Pagination: 229-31 Citation Subset: IM |
Affiliation:
|
Department of Pediatric Nephrology, University Children's Hospital, 17 Vodnjanska, 1000 Skopje, Macedonia. vtasic@freemail.com.mk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adjuvants, Immunologic
/
therapeutic use* Autoantibodies / blood Child Child, Preschool Dose-Response Relationship, Drug Drug Administration Schedule Drug Therapy, Combination Female Follow-Up Studies Humans Immunosuppressive Agents / adverse effects, therapeutic use* Levamisole / therapeutic use* Nephrosis, Lipoid / complications*, diagnosis, drug therapy* Prednisone / adverse effects, therapeutic use* Recurrence Thyroid Gland / immunology Thyroiditis, Autoimmune / complications*, diagnosis |
| Chemical | |
Reg. No./Substance:
|
0/Adjuvants, Immunologic; 0/Autoantibodies; 0/Immunosuppressive Agents; 14769-73-4/Levamisole; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic inflammatory demyelinating polyneuropathy as a possible novel component of autoimmune poly-e...
Next Document: Neonatal transient respiratory depression after maternal urapidil infusion for hypertension.