| Autoimmune pancreatitis: a report from India. | |
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MedLine Citation:
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PMID: 20442514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Autoimmune pancreatitis is characterized by immune-mediated inflammation, prominent lymphocytic infiltration and fibrosis of pancreas. It accounts for 4.6-6% of chronic pancreatitis but only a few cases from India have been reported. OBJECTIVE: Evaluation of cases of autoimmune pancreatitis diagnosed between July 2006 and June 2009. DESIGN: Retrospective analysis of the clinical records of all patients diagnosed as autoimmune pancreatitis between July 2006 and June 2009. SETTING: Tertiary care centre, northern India. MAIN OUTCOME MEASURE: Clinical records of all patients with autoimmune pancreatitis were analyzed with respect to their initial diagnosis and treatment, imaging, cytology, serology, presence of other organ involvement and response to treatment. RESULTS: The 5 cases of autoimmune pancreatitis included 4 men and one woman ranging in age from 48 to 60 years. The interval between initial consultation and diagnosis ranged from 3 months to 7 years. Symptoms included obstructive jaundice (5/5), abdominal pain (3/5) and weight loss (3/5). In 3 cases a presumptive diagnosis of a pancreatic mass with a biliary stricture was made and, in one patient, the diagnosis of primary sclerosing cholangitis was considered. These four patients had received a biliary stent and it was only on follow-up and review of the repeat CT scan that a diagnosis of autoimmune pancreatitis was suggested. In one patient, a diagnosis of autoimmune pancreatitis was considered in the first instance. Radiologically, all 5 patients showed a bulky pancreas with loss of lobulations. CONCLUSION: In this report from India, we highlight the need for a high index of suspicion in diagnosing autoimmune pancreatitis because it responds dramatically to steroids. |
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Authors:
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Mohd T Noor; Anupam Lal; Rakesh Kochhar; Manphool Singhal; Gurbakshish S Sidhu; Radhika Srinivasan; Amit Rawat; Usha Dutta; Radha K Dhiman; Yogesh K Chawla; Kartar Singh |
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Publication Detail:
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Type: Journal Article Date: 2010-05-05 |
Journal Detail:
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Title: JOP : Journal of the pancreas Volume: 11 ISSN: 1590-8577 ISO Abbreviation: JOP Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101091810 Medline TA: JOP Country: Italy |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases*
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drug therapy,
pathology,
radiography Biopsy, Fine-Needle Cholangiopancreatography, Endoscopic Retrograde Female Follow-Up Studies Glucocorticoids / therapeutic use* Humans Immunoglobulin G / blood India Male Middle Aged Pancreatitis* / drug therapy, pathology, radiography Prednisolone / therapeutic use* Retrospective Studies Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunoglobulin G; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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