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Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis.
MedLine Citation:
PMID:  21654717     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The different autoimmune myopathies-for example, dermatomyositis, polymyositis, and immune-mediated necrotizing myopathies (IMNM)-have unique muscle biopsy findings, but they also share specific clinical features, such as proximal muscle weakness and elevated serum levels of muscle enzymes. Furthermore, around 60% of patients with autoimmune myopathy have been shown to have a myositis-specific autoantibody, each of which is associated with a distinct clinical phenotype. The typical clinical presentations of the autoimmune myopathies are reviewed here, and the different myositis-specific autoantibodies, including the anti-synthetase antibodies, dermatomyositis-associated antibodies, and IMNM-associated antibodies, are discussed in detail. This Review also focuses on a newly recognized form of IMNM that is associated with statin use and the production of autoantibodies that recognize 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the pharmacological target of statins. The contribution of interferon signaling to the development of dermatomyositis and the potential link between malignancies and the initiation of autoimmune myopathies are also assessed.
Authors:
Andrew L Mammen;
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Publication Detail:
Type:  Journal Article     Date:  2011-06-08
Journal Detail:
Title:  Nature reviews. Neurology     Volume:  7     ISSN:  1759-4766     ISO Abbreviation:  Nat Rev Neurol     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500072     Medline TA:  Nat Rev Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  343-54     Citation Subset:  IM    
Affiliation:
Departments of Neurology and Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins Myositis Center, Mason F. Lord Building Center Tower, Suite 4500, Baltimore, MD 21224, USA. USA.amammen@jhmi.edu.
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