Document Detail

Autoimmune limbic encephalitis: a reversible form of rapidly progressive amnesia and seizures.
MedLine Citation:
PMID:  21125054     Owner:  NLM     Status:  MEDLINE    
Many forms of rapidly progressive cognitive impairment are irreversible and rarely treatable. We present a case of autoimmune limbic encephalitis associated with voltage-gated potassium channel autoantibodies that led to rapid cognitive deterioration and bizarre behaviour, which subsequently improved following immunosuppressant therapy. The diagnosis of autoimmune limbic encephalitis needs to be considered in patients presenting with apparent viral encephalitis, in more unusual clinical situations in subjects with acute psychiatric illness and in cases of refractory epilepsy, particularly if there is evidence of amnesia. The diagnosis depends on the detection of specific antibodies directed against central nervous system targets. There can be a good response to immunosuppressant therapy.
A Ahmad; S Ramakrishna; J Meara; M Doran
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of the Royal College of Physicians of Edinburgh     Volume:  40     ISSN:  1478-2715     ISO Abbreviation:  J R Coll Physicians Edinb     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-12-02     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101144324     Medline TA:  J R Coll Physicians Edinb     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  IM    
North Manchester General Hospital, Crumpsall, UK.
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MeSH Terms
Amnesia / complications*,  drug therapy
Autoimmune Diseases / complications*,  diagnosis,  drug therapy
Diagnosis, Differential
Disease Progression
Immunosuppressive Agents / therapeutic use
Limbic Encephalitis / complications*,  diagnosis,  drug therapy
Magnetic Resonance Imaging
Middle Aged
Seizures / complications*,  drug therapy
Reg. No./Substance:
0/Immunosuppressive Agents

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