Document Detail


Autoimmune limbic encephalitis as an emerging pediatric condition: case report and review of the literature.
MedLine Citation:
PMID:  21183722     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Limbic encephalitis, first described in the 1960s as a paraneoplastic condition, has emerged as an autoimmune condition, occurring often without evidence of an underlying tumor. Many novel autoantibodies have been identified, and this diagnosis is increasingly being made in the pediatric population. This article reports the case of a 16-year-old boy who presented following gastrointestinal illness with subacute evolution of neuropsychiatric symptoms. Brain magnetic resonance imaging revealed progressive hippocampal signal abnormality and swelling. N-methyl-D-aspartate (NMDA) receptor antibody was detected in serum. The patient responded well to pharmacological immunotherapy but has residual cognitive deficits. The available literature on this condition is reviewed. Limbic encephalitis should be considered in the differential diagnosis in children presenting with encephalopathy, particularly with neuropsychiatric manifestations. Long-term surveillance and close follow-up are required to accurately clarify tumor risk and natural history of this condition in children and balance these factors with risks of radiation exposure through imaging.
Authors:
Bláthnaid McCoy; Tomoyuki Akiyama; Elysa Widjaja; Cristina Go
Publication Detail:
Type:  Journal Article     Date:  2010-12-23
Journal Detail:
Title:  Journal of child neurology     Volume:  26     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  218-22     Citation Subset:  IM    
Affiliation:
The Hospital for Sick Children, Toronto, Ontario, Canada. blathmccoy@yahoo.co.uk / blathnaid.mccoy@sickkids.ca.
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