Document Detail

Autoimmune hepatitis overlapping with primary sclerosing cholangitis.
MedLine Citation:
PMID:  12322794     Owner:  NLM     Status:  MEDLINE    
A case of autoimmune hepatitis (AIH) complicated by primary sclerosing cholangitis (PSC) in a 36-year-old woman is reported. AIH overlapping with PSC has been rarely reported, and to the best of our knowledge, there have been no reports in Japan. Based on the criteria for diagnosis of AIH and on typical endoscopic retrograde cholangiograph (ERC) findings, the patient was diagnosed as having AIH overlapping with PSC. Her transaminase levels normalized within 1 month after administration of prednisone, azathioprine and ursodeoxycholic acid, but her cholestatic enzyme level remained elevated. The effect of treatment on the cholestatic features is thought to be an important factor for predicting the prognosis of AIH overlapping with PSC.
Junko Takiguchi; Hiromasa Ohira; Tsuyoshi Rai; Shoichiro Shishido; Jun Tojo; Yukio Sato; Reiji Kasukawa; Hiroshi Watanabe; Yuji Funabashi; Hiromi Kumakawa
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  41     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-26     Completed Date:  2003-03-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  696-700     Citation Subset:  IM    
Second Department of Internal Medicine, Fukushima Medical University School of Medicine.
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MeSH Terms
Autoantibodies / blood
Azathioprine / therapeutic use
Cholangiopancreatography, Endoscopic Retrograde
Cholangitis, Sclerosing / complications*,  drug therapy,  pathology
Glucocorticoids / therapeutic use
Hepatitis, Autoimmune / complications*,  drug therapy,  pathology
Immunosuppressive Agents / therapeutic use
Liver / pathology*,  radiography
Liver Function Tests
Prednisone / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Autoantibodies; 0/Glucocorticoids; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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