Document Detail


Autoimmune hepatitis during infliximab therapy for Crohn's disease: a case report.
MedLine Citation:
PMID:  21575891     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present the case of a 60-year-old Caucasian male with Crohn's disease treated with infliximab. Within 14 weeks of treatment induction, an asymptomatic acute hepatitis was detected. Elevated autoantibodies and liver biopsy findings supported the diagnosis of autoimmune hepatitis. No competing aetiologies were present. The hepatitis completely responded to infliximab cessation and administration of corticosteroids. This case is the most compelling to date of an infliximab-induced autoimmune hepatitis. Although the role of liver enzyme monitoring is unclear, an awareness of this adverse effect is important, given the potential for a rapid and complete response to specific treatment.
Authors:
Adam Doyle; Geoff Forbes; Nick Kontorinis
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-11
Journal Detail:
Title:  Journal of Crohn's & colitis     Volume:  5     ISSN:  1876-4479     ISO Abbreviation:  J Crohns Colitis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-11-08     Revised Date:  2012-06-22    
Medline Journal Info:
Nlm Unique ID:  101318676     Medline TA:  J Crohns Colitis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Gastroenterology and Hepatology, Royal Perth Hospital, Western Australia. doyle.adam@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / adverse effects*,  therapeutic use
Antibodies, Monoclonal / adverse effects*,  therapeutic use
Crohn Disease / drug therapy*
Hepatitis, Autoimmune / etiology*
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/infliximab
Comments/Corrections
Comment In:
J Crohns Colitis. 2012 Jun;6(5):630-1   [PMID:  22398075 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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