Document Detail


Autoimmune hepatitis among fertile women: strategies during pregnancy and breastfeeding?
MedLine Citation:
PMID:  17613929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In published studies there is a lack of data about the risks, management and how women with autoimmune hepatitis (AIH) decide on and are advised about pregnancy. The aim of this study was to investigate how women with AIH consider pregnancies, are advised and pharmacologically treated, as well as the outcome. MATERIAL AND METHODS: A questionnaire was mailed to 128 women with AIH diagnosed during their fertile period and data from the Swedish National Birth Register was also used for matched controls. RESULTS: There was an 83% response rate to the questionnaires. Sixty-three pregnancies were reported by 35 women. 48% did not consult their doctors before getting pregnant. More than half of the women reduced or stopped the immune suppression during pregnancy or breastfeeding. Some women were advised to abstain from pregnancy or even to have an abortion. Caesarean sections were performed more frequently in the AIH group (16% compared with 6.5% in the control group p<0.01). There were no significant differences in the number of stillborn infants or infants with malformations. However, 30% of the patients experienced flare-up after delivery. CONCLUSIONS: In general, the outcome of pregnancy in women with AIH seems to be good. Current pharmacological treatment appears to be safe, including azathioprine during pregnancy and lactation. After delivery an active preparedness to increase pharmacotherapy should be considered.
Authors:
Mårten Werner; Einar Björnsson; Hanne Prytz; Stefan Lindgren; Sven Almer; Ulrika Broomé; Sven Wallerstedt; Hanna Sandberg-Gertzén; Rolf Hultcrantz; Per Sangfeldt; Jenny Nilsson; Ake Danielsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  42     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-10-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  986-91     Citation Subset:  IM    
Affiliation:
Departments of Medicine, Sections for Hepatology and Gastroenterology, Umeå University Hospital, Umeå, Sweden. marten.werner@vll.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Breast Feeding*
Female
Fertility
Hepatitis, Autoimmune / drug therapy*
Humans
Middle Aged
Pregnancy
Questionnaires

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