Document Detail


Autoimmune hemolytic anemia in children.
MedLine Citation:
PMID:  17613874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical and hematological profile and treatment outcome of children with warm autoimmune hemolytic anemia (AIHA) were assessed using retrospective case record analysis. There were 26 (17 idiopathic; 9 secondary) patients with a median age of 11 years. Pallor (100%), fever (39%), and jaundice (59%) were the main presenting complaints. Jaundice was much more common in idiopathic (70%) compared to secondary (44%). Direct antiglobulin test was negative in 3 patients. Oral prednisolone produced remission in 81% patients. Four patients relapsed after a median period of 7 months (2 months to 2 year) after response. All responded to a second course of steroids in median 14 days. One child required cyclosporin A in addition. No correlation was found between response and parameters such as age, sex, jaundice, low pretreatment hemoglobin, reticulocyte count, total leukocyte count, platelet count, subtype of AIHA, and hepatosplenomegaly. Relapse correlated with increased duration between the onset of symptoms and treatment. This study indicates that oral prednisolone is an effective therapy for autoimmune hemolytic anemia. In refractory cases cyclosporine A may be useful.
Authors:
Rahul Naithani; Neerja Agrawal; M Mahapatra; Rajat Kumar; H P Pati; V P Choudhry
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  24     ISSN:  1521-0669     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-06     Completed Date:  2007-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  309-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anemia, Hemolytic, Autoimmune / drug therapy*,  pathology*
Child
Child, Preschool
Female
Fever
Humans
Infant
Jaundice
Male
Pallor
Prednisolone / therapeutic use
Recurrence
Remission Induction
Retrospective Studies
Chemical
Reg. No./Substance:
50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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