Document Detail


Autoimmune hemolytic anemia in Philadelphia positive chronic myeloid leukemia with t(7;14) anomaly after 5 years of interferon alpha treatment.
MedLine Citation:
PMID:  12412737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 41-year-old woman, Philadelphia positive chronic myeloid leukemia patient, had progressive decline in hemoglobin levels. She had been receiving interferon alpha treatment for five years. Autoimmune hemolytic anemia was diagnosed. Subsequent bone marrow examination revealed translocation t(7;14). She was placed on prednisone treatment. The patient responded to prednisone as treatment for the hemolytic process. The result of a direct Coombs' test remained positive. The patient died shortly after the diagnosis of autoimmune hemolytic anemia. Autoimmune hemolytic anemia should be considered in the evaluation of chronic myeloid leukemia patients with a sudden decrease in hemoglobin levels.
Authors:
Aydin Köksal; Düzgün Ozatli; Ibrahim C Haznedaroğlu; Asuman Sunguroğlu; Sema Karakuş; Yahya Büyükaşik
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Haematologia     Volume:  32     ISSN:  0017-6559     ISO Abbreviation:  Haematologia (Budap)     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-06-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0130266     Medline TA:  Haematologia (Budap)     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Affiliation:
Kirikkale University Medical School, Department of Internal Medicine, Turkey. dckoksal@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Hemolytic, Autoimmune / diagnosis,  etiology*
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 7
Cytogenetic Analysis
Fatal Outcome
Female
Humans
Interferon-alpha / administration & dosage
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*,  drug therapy,  genetics
Translocation, Genetic
Chemical
Reg. No./Substance:
0/Interferon-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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