Document Detail


Autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura in pediatric solid organ transplant recipients, report of five cases and review of the literature.
MedLine Citation:
PMID:  22112003     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Miloh T, Arnon R, Roman E, Hurlet A, Kerkar N, Wistinghausen B. Autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura in pediatric solid organ transplant recipients, report of five cases and review of the literature. Pediatr Transplantation 2011: 15: 870-878. © 2011 John Wiley & Sons A/S. Abstract:  Cytopenias are common among pediatric SOT; however, autoimmune cytopenias are infrequently reported. We report five cases of autoimmune cytopenias in pediatric LT patients: two with isolated IgG-mediated AIHA, two with ITP, and one with Evans syndrome (ITP and AIHA). All patients were maintained on tacrolimus as immunosuppression. Viral illness commonly preceded the autoimmune cytopenias. All patients responded well to medical therapy (steroids, intravenous immunoglobulin, and rituximab) and lowering tacrolimus serum level. Prognosis appears to be worse when more than one cell line (e.g., Evans syndrome) is affected, and/or there is no preceding viral illness. A critical literature review of autoimmune cytopenias in children following SOT is conducted. Autoimmune cytopenias are a rarely reported complication of pediatric SOT, but clinicians taking care of pediatric transplant recipients need to be aware of this complication.
Authors:
Tamir Miloh; Ronen Arnon; Elizabeth Roman; Anne Hurlet; Nanda Kerkar; Birte Wistinghausen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric transplantation     Volume:  15     ISSN:  1399-3046     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  870-8     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Gastroenterology, Phoenix Children's Hospital, Phoenix, AZ, USA Clinical Pediatrics, University of Arizona College of Medicine, Phoenix, AZ, USA Department of Pediatrics and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY, USA Jack Martin Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA.
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