Document Detail


Autoimmune hemolytic anemia associated with anti-Sc1.
MedLine Citation:
PMID:  1542925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of autoimmune hemolytic anemia (AIHA) in a young child is described. The hemolysis was resistant to steroid therapy but responded to splenectomy and intravenous immunoglobulin. The autoantibody was shown to be anti-Sc1 by both serologic and immunoblotting techniques. This seems to be the first report of an autoanti-Sc1 detected by immunoblotting and the first example of AIHA in a child caused by autoanti-Sc1.
Authors:
I Owen; V Chowdhury; M E Reid; J Poole; J C Marsh; J M Hows
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Transfusion     Volume:  32     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-04-07     Completed Date:  1992-04-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  IM    
Affiliation:
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Hemolytic, Autoimmune / immunology*,  therapy
Autoantibodies / analysis*
Autoantigens / immunology*
Female
Humans
Immunization, Passive
Immunoblotting
Immunoglobulin G / analysis
Infant
Ribonucleoproteins, Small Nuclear*
Splenectomy
snRNP Core Proteins
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Autoantigens; 0/Immunoglobulin G; 0/Ribonucleoproteins, Small Nuclear; 0/snRNP Core Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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