Document Detail


Autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia treated with 2-chlorodeoxyadenosine (cladribine).
MedLine Citation:
PMID:  9111592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune haemolytic anaemia (AIHA) is one of the major complications in chronic lymphocytic leukaemia (CLL). Treatment with alkylating agents and the adenosine analogue, fludarabine, might trigger the development of AIHA in CLL patients despite the reduction of leukaemic clone. The influence of 2-chlorodeoxyadenosine (2-CdA) on AIHA in patients with CLL is undefined so far. In a group of 114 patients treated at our clinics with this agent, AIHA with direct antiglobulin test (DAT) positively was observed in 25 (21.9%) patients. In 23 patients AIHA was noticed before the starting of 2-CdA and in 2 patients DAT became positive after 2-CdA treatment. In 6 patients the drug caused complete resolution of haemolysis and DAT became negative. Eight patients exhibited partial resolution of haemolysis with significant improvement in haemoglobin level but DAT test remained positive. In 11 patients there was no response to 2-CdA in relation to autoimmune haemolysis. Two patients with no previous history of haemolysis developed AIHA after 5 and 6 courses of 2-CdA therapy and their DAT became positive 1-2 months after the last course of the drug. One of them entered severe haemolytic crisis and severe thrombocytopenia and died because of haemorrhagy to the central nervous system. In the other patient AIHA was controlled by steroids and chlorambucil treatment. Our study indicates that 2-CdA may suppress autoimmunohaemolytic process in some patients with CLL and trigger the development of AIHA in others.
Authors:
T Robak; M Błasińska-Morawiec; E Krykowski; A Hellmann; L Konopka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  58     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-12     Completed Date:  1997-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  109-13     Citation Subset:  IM    
Affiliation:
Department of Hematology, Medical University of Lódź, Poland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Hemolytic, Autoimmune / blood,  epidemiology,  etiology*
Antigens, CD / blood
Antineoplastic Agents / therapeutic use*
B-Lymphocytes / immunology
Cladribine / therapeutic use*
Coombs' Test
Female
Hemolysis
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / complications*,  drug therapy*
Male
Middle Aged
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antineoplastic Agents; 4291-63-8/Cladribine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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