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Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases.
MedLine Citation:
PMID:  22465972     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AIM: To assess the prevalence of concurrent extrahepatic autoimmune diseases in patients with autoimmune hepatitis (AIH)/primary biliary cirrhosis (PBC) overlap syndrome and applicability of the 'mosaic of autoimmunity' in these patients.
METHODS: The medical data of 71 AIH/PBC overlap patients were evaluated for associated autoimmune diseases.
RESULTS: In the study population, 31 (43.6%) patients had extrahepatic autoimmune diseases, including autoimmune thyroid diseases (13 patients, 18.3%), Sjögren syndrome (six patients, 8.4%), celiac disease (three patients, 4.2%), psoriasis (three patients, 4.2%), rheumatoid arthritis (three patients, 4.2%), vitiligo (two patients, 2.8%), and systemic lupus erythematosus (two patients, 2.8%). Autoimmune hemolytic anemia, antiphospholipid syndrome, multiple sclerosis, membranous glomerulonephritis, sarcoidosis, systemic sclerosis, and temporal arteritis were identified in one patient each (1.4%). A total of 181 autoimmune disease diagnoses were found in our patients. Among them, 40 patients (56.4%) had two, 23 (32.3%) had three, and eight (11.3%) had four diagnosed autoimmune diseases.
CONCLUSION: A large number of autoimmune diseases were associated with AIH/PBC overlap patients. Therefore, extended screening for existing autoimmune diseases during the routine assessment of these patients is recommended. Our study suggests that the concept of 'mosaic of autoimmunity' is a valid clinical entity that is applicable to patients with AIH/PBC overlap syndrome.
Authors:
Cumali Efe; Staffan Wahlin; Ersan Ozaslan; Alexandra Heurgue Berlot; Tugrul Purnak; Luigi Muratori; Chiara Quarneti; Osman Yüksel; Gérard Thiéfin; Paolo Muratori
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  24     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
Affiliation:
aDepartment of Gastroenterology, Numune Research and Education Hospital bDepartment of Gastroenterology, Ankara Diskapi Education and Research Hospital, Ankara, Turkey cDepartment of Gastroenterology and Hepatology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden dDepartment of Hepato-Gastroenterology, CHU Reims, Reims, France eDepartment of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
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