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Autoimmune Pulmonary Alveolar Proteinosis: Treatment Options In The Year 2012.
MedLine Citation:
PMID:  23036113     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by accumulation of a periodic acid-Schiff (PAS)-positive eosinophilic material in the distal airways. For decades, standard treatment of PAP has been whole lung lavage (WLL), where large quantities of saline are instilled into the lungs to remove the proteinaceous material. However, not all patients respond to this treatment. Thus new treatment modalities such as subcutaneous or inhaled granulocyte macrophage colony stimulating factor (GM-CSF), the CD20 antibody rituximab and plasmapheresis have been investigated. Based on the current literature a stepwise treatment plan is suggested starting with WLL, continuing to inhaled GM-CSF and then to rituximab if the former treatment regimes are unsuccessful. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Authors:
Steffen Leth; Elisabeth Bendstrup; Hanne Vestergaard; Ole Hilberg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  -     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
Affiliation:
Dept. of Respiratory Diseases and Allergology, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark. Dept. of Hematology, Odense University Hospital, Sdr. boulevard 29, 5000 Odense C, Denmark.
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