Document Detail

Autoimmune polyendocrine syndrome-3 in a patient with late-onset multiple sclerosis.
MedLine Citation:
PMID:  22367836     Owner:  NLM     Status:  MEDLINE    
We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient.
Hiroaki Yokote; Miki Nagasawa; Masahiko Ichijo; Takeshi Amino; Hiroto Fujigasaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The neurologist     Volume:  18     ISSN:  2331-2637     ISO Abbreviation:  Neurologist     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-11-06     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  9503763     Medline TA:  Neurologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-4     Citation Subset:  IM    
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MeSH Terms
Age of Onset
Asian Continental Ancestry Group / genetics
Genetic Predisposition to Disease / genetics*
HLA-DR4 Antigen / genetics
Multiple Sclerosis / complications*
Polyendocrinopathies, Autoimmune / complications*,  diagnosis,  genetics*
Reg. No./Substance:
0/HLA-DR4 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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