| Autoimmune pancreatitis associated with myelodysplastic syndrome. | |
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MedLine Citation:
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PMID: 19752571 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 65-year-old man with myelodysplastic syndrome (MDS) was admitted for progressive jaundice. Diffuse pancreatic swelling and stricture of the main pancreatic duct were observed with elevated serum levels of direct bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, gammaGTP and amylase, and impaired glucose tolerance. Serum IgG and IgG4 levels were highly elevated, and both the direct antiglobulin test and platelet-associated IgG were positive. He was diagnosed with autoimmune pancreatitis associated with MDS, and biliary drainage followed by immunosuppressive therapy ameliorated the jaundice and laboratory findings. In addition to diffuse pancreatic FDG accumulation, fine incorporations of FDG to the lachrymal and submandibular glands were demonstrated, suggesting the recently proposed IgG4+ multiorgan lymphoproliferative syndrome (MOLPS). The etiology of IgG4+ MOLPS is still unknown; however, autoantibodies to blood cells in this case suggested that the autoimmune mechanism, which is caused by abnormal immune functions in MDS patients, might be involved in the pathogenesis of IgG4+ MOLPS. |
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Authors:
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Rie Tabata; Chiharu Tabata; Tomoko Okamoto; Konosuke Omori; Makoto Terada; Tomoko Nagai |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-15 |
Journal Detail:
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Title: International archives of allergy and immunology Volume: 151 ISSN: 1423-0097 ISO Abbreviation: Int. Arch. Allergy Immunol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9211652 Medline TA: Int Arch Allergy Immunol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 168-72 Citation Subset: IM |
Copyright Information:
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2009 S. Karger AG, Basel. |
Affiliation:
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Department of Internal Medicine, Hyogo Prefectural Tsukaguchi Hospital, Hyogo, Japan. rtabata@hp.pref.hyogo.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amylases / blood Autoantibodies / blood, immunology Autoimmune Diseases / drug therapy, etiology*, pathology Azathioprine / therapeutic use Bile Ducts / pathology Bilirubin / blood Blood Cells / immunology, pathology Bone Marrow / pathology Humans Male Myelodysplastic Syndromes / complications*, drug therapy, pathology Pancreas / pathology Pancreatic Ducts / pathology Pancreatitis / drug therapy, etiology*, pathology Pancytopenia / drug therapy, pathology Platelet Count Prednisolone / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 446-86-6/Azathioprine; 50-24-8/Prednisolone; 635-65-4/Bilirubin; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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