Document Detail

Autofluorescence bronchoscopy in volunteer asymptomatic smokers.
MedLine Citation:
PMID:  19356646     Owner:  NLM     Status:  MEDLINE    
We assess the sensitivity of autofluorescence bronchoscopy (AFB) compared to that of white light bronchoscopy (WLB) for identification of pre-invasive neoplastic changes of bronchial mucosa in asymptomatic heavy smokers. WLB was performed using a standard flexible fibre-optic bronchoscope, and AFB carried out using the Xillix LIFE Lung((R)) system. Positive AFB images were indicated in the bronchial tree from 51 of the 93 subjects in the study. Biopsies showed epithelial abnormalities in 27 (15 metaplasia, 12 inflammatory changes) of these. WLB showed abnormality in 1 subject but with no pathological changes revealed by cyto-histology. Therefore, the sensitivity of AFB to metaplasia was 75% compared to zero for WLB. AFB yields positive predictive values for metaplastic and overall mucosal changes of 29.4% and 52.9%, respectively. In summary, over 16% of asymptomatic smokers had metaplastic changes in their bronchial mucosa, and AFB proved more sensitive in revealing early changes than WLB.
M R Stringer; K Moghissi; K Dixon
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-07-07
Journal Detail:
Title:  Photodiagnosis and photodynamic therapy     Volume:  5     ISSN:  1873-1597     ISO Abbreviation:  Photodiagnosis Photodyn Ther     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101226123     Medline TA:  Photodiagnosis Photodyn Ther     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Institute of Microwaves and Photonics, School of Electronic and Electrical Engineering, University of Leeds, Woodhouse Lane, Leeds LS29JT, UK.
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MeSH Terms
Bronchi / cytology,  pathology
Microscopy, Fluorescence*
Middle Aged
Nontherapeutic Human Experimentation
Precancerous Conditions / diagnosis*
Prospective Studies
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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