Document Detail

Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma.
MedLine Citation:
PMID:  17062276     Owner:  NLM     Status:  MEDLINE    
We report the first case of a malignant mesothelioma expressing not only granulocyte-colony stimulating factor (G-CSF), but also its receptor. A 59-year-old male carpenter underwent a panpleuropneumonectomy, but the tumor relapsed and spread rapidly, accompanied by leukocytosis. The white blood cell count reached 147,000/mm3 (96.2% neutrophils), and the concentration of serum G-CSF was 77 pg/mL. An autopsy demonstrated that some of the tumor cells produced G-CSF, but more tumor cells and endothelial cells in the tumor expressed G-CSF receptor. It was hypothesized that an autocrine loop involving G-CSF and the G-CSF receptor greatly accelerated the tumor growth.
Motohiro Nishimura; Kyoko Itoh; Kazuhiro Ito; Masashi Yanada; Kunihiko Terauchi; Shinji Fushiki; Junichi Shimada
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  82     ISSN:  1552-6259     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1904-6     Citation Subset:  AIM; IM    
Department of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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MeSH Terms
Abdominal Neoplasms / metabolism*,  secondary
Autocrine Communication*
Fatal Outcome
Granulocyte Colony-Stimulating Factor / biosynthesis*
Mesothelioma / metabolism*,  secondary
Middle Aged
Pleural Neoplasms / metabolism*,  pathology
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis
Reg. No./Substance:
0/Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; 143011-72-7/Granulocyte Colony-Stimulating Factor

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