| Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma. | |
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MedLine Citation:
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PMID: 17062276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the first case of a malignant mesothelioma expressing not only granulocyte-colony stimulating factor (G-CSF), but also its receptor. A 59-year-old male carpenter underwent a panpleuropneumonectomy, but the tumor relapsed and spread rapidly, accompanied by leukocytosis. The white blood cell count reached 147,000/mm3 (96.2% neutrophils), and the concentration of serum G-CSF was 77 pg/mL. An autopsy demonstrated that some of the tumor cells produced G-CSF, but more tumor cells and endothelial cells in the tumor expressed G-CSF receptor. It was hypothesized that an autocrine loop involving G-CSF and the G-CSF receptor greatly accelerated the tumor growth. |
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Authors:
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Motohiro Nishimura; Kyoko Itoh; Kazuhiro Ito; Masashi Yanada; Kunihiko Terauchi; Shinji Fushiki; Junichi Shimada |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 82 ISSN: 1552-6259 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-25 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1904-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Neoplasms
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metabolism*,
secondary Ascites Autocrine Communication* Fatal Outcome Granulocyte Colony-Stimulating Factor / biosynthesis* Humans Male Mesothelioma / metabolism*, secondary Middle Aged Pleural Neoplasms / metabolism*, pathology Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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